%0 Journal Article
%T The Dynamic Processing of CD46 Intracellular Domains Provides a Molecular Rheostat for T Cell Activation
%A Siobhan Ni Choileain
%A Nathan J. Weyand
%A Christian Neumann
%A Joelle Thomas
%A Magdalene So
%A Anne L. Astier
%J PLOS ONE
%D 2012
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0016287
%X Adequate termination of an immune response is as important as the induction of an appropriate response. CD46, a regulator of complement activity, promotes T cell activation and differentiation towards a regulatory Tr1 phenotype. This Tr1 differentiation pathway is defective in patients with MS, asthma and rheumatoid arthritis, underlying its importance in controlling T cell function and the need to understand its regulatory mechanisms. CD46 has two cytoplasmic tails, Cyt1 and Cyt2, derived from alternative splicing, which are co-expressed in all nucleated human cells. The regulation of their expression and precise functions in regulating human T cell activation has not been fully elucidated.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0016287