%0 Journal Article
%T Autoantibodies, human Fc¦Ã receptors, and autoimmunity
%A Margherita Sisto
%A Sabrina Lisi
%A Simona D¡¯Amore
%A et al
%J Journal of Receptor, Ligand and Channel Research
%D 2009
%I 
%R http://dx.doi.org/10.2147/JRLCR.S6947
%X utoantibodies, human Fc¦Ã receptors, and autoimmunity Review (6316) Total Article Views Authors: Margherita Sisto, Sabrina Lisi, Simona D¡¯Amore, et al Published Date November 2009 Volume 2009:2 Pages 45 - 57 DOI: http://dx.doi.org/10.2147/JRLCR.S6947 Margherita Sisto1,3, Sabrina Lisi1,3, Simona D¡¯Amore2, Massimo D¡¯Amore2 1Department of Human Anatomy and Histology, Cell Biology Section, 2Department of Internal Medicine and Public Medicine, Rheumatology Section, University of Bari Medical School, Bari, Italy; 3The first two authors have equal contribution in this work and both are equally considered the first authors Abstract: Receptors for the Fc fragment of immunoglobulin G (Fc¦ÃRs) represent the link between the humoral and cellular immune responses. In humans, three different types of Fc¦ÃRs belonging to the immunoglobulin gene superfamily, have been identified; Fc¦ÃRI (cluster of differentiation (CD64), Fc¦ÃRII (CD32) and Fc¦ÃRIII (CD16). Fc¦ÃRs are important molecules not only to mediate and control the effectors functions of immunoglobulin G antibodies, but they also control the autoimmunity¨Ctolerance balance in the periphery. The development of autoimmune diseases is complex and dependent on multiple genes and environmental factors. A wide range of inflammatory and autoimmune diseases such as vasculitis, glomerulonephritis, and autoimmune hemolytic anemia, seems to be mediated, in part, by Fc¦ÃRs. Considering that the autoantibodies target intracellularly located antigens, recent findings supposed that, under certain conditions, Fc¦ÃRs are involved in the penetration of antibodies into cells and Fc¦ÃRs constitute one of the main effector mechanisms through which autoantibodies exert their action. In this review we concentrate on the role of human Fc¦ÃRs in autoantibodies penetration and summarize the current knowledge on the structure, ligand-binding capacity, and their role in autoimmunity and pathogenic effect of autoantibodies. These novel insights into antibody FcR interactions might be useful to produce the next generation of improved immunotherapeutic molecules.
%K autoantibodies
%K Fc¦ÃReceptors
%K IgG
%K adalimumab
%K salivary gland
%U https://www.dovepress.com/autoantibodies-human-fcgamma-receptors-and-autoimmunity-peer-reviewed-article-JRLCR