%0 Journal Article
%T Mantle cell leukemia as a cause of leukostasis
%A Smith D
%A Cable C
%A Chisholm C
%A Linz W
%A Koss W
%A Dobin S
%A Rappaport E
%J Blood and Lymphatic Cancer: Targets and Therapy
%D 2011
%I 
%R http://dx.doi.org/10.2147/BLCTT.S17157
%X ntle cell leukemia as a cause of leukostasis Case report (2402) Total Article Views Authors: Smith D, Cable C, Chisholm C, Linz W, Koss W, Dobin S, Rappaport E Published Date April 2011 Volume 2011:1 Pages 5 - 8 DOI: http://dx.doi.org/10.2147/BLCTT.S17157 Daniel Smith1, Christian Cable2, Cary Chisholm1, Walter Linz1, William Koss1, Sheila Dobin1, Edward Rappaport1 1Department of Pathology, 2Internal Medicine, Scott and White Healthcare/Texas A & M Health Science Center College of Medicine, Temple, TX, USA Abstract: A 72-year-old man was admitted with hypoxemic respiratory distress. Given a white blood cell count of 600 กม 109/L and symptoms of leukostasis, emergency leukapheresis was initiated. The white blood cell count immediately after the first leukapheresis was paradoxically increased to over 700 กม 109/L. Peripheral blood smear findings showed morphologically immature mononuclear cells and numerous circulating mitotic figures. Initial flow cytometry results showed a lambda light chain-restricted B lymphoid population positive for CD20, CD19, CD5, and FMC-7, and negative for TdT, CD10, CD23, CD34, CD117, and myeloid markers, suggesting classification as a blastoid variant of mantle cell lymphoma in a leukemic phase. Subsequent testing using DNA fluorescence in situ hybridization was positive for t(11;14), confirming the diagnosis of mantle cell leukemia. Although mantle cell lymphoma occasionally transforms or can even present as leukemia (leukocytes >40 กม 109/L), it is rare for it to present with such profound leukocytosis and an overwhelming number of pleomorphic/blastoid forms. Although morphology suggested acute lymphoblastic leukemia, a more specific diagnosis of blastoid variant mantle cell lymphoma was obtained in 12 hours by applying complementary techniques of flow cytometry and rapid cytogenetics.
%K mantle cell lymphoma
%K chemotherapy
%K leukapheresis
%K lymphocytic leukemia
%U https://www.dovepress.com/mantle-cell-leukemia-as-a-cause-of-leukostasis-peer-reviewed-article-BLCTT