%0 Journal Article
%T Actin dynamics at the immunological synapse
%A M車nica Gord車n-Alonso
%A Esteban Veiga
%A Francisco S芍nchez-Madrid
%J Cell Health and Cytoskeleton
%D 2010
%I 
%R http://dx.doi.org/10.2147/CHC.S9960
%X ctin dynamics at the immunological synapse Review (4782) Total Article Views Authors: M車nica Gord車n-Alonso, Esteban Veiga, Francisco S芍nchez-Madrid Published Date June 2010 Volume 2010:2 Pages 33 - 47 DOI: http://dx.doi.org/10.2147/CHC.S9960 M車nica Gord車n-Alonso, Esteban Veiga, Francisco S芍nchez-Madrid Servicio de Inmunolog赤a, Hospital Universitario de la Princesa and Facultad de Medicina, Universidad Aut車noma de Madrid, Diego de Le車n, Madrid, Spain Abstract: Actins are a family of highly conserved proteins that play determinant roles in a variety of biological processes including: cell shape; migration; endocytosis/exocytosis; and adhesion. The dynamics of actin polymerization and depolymerization at specific cellular locations is tightly regulated and defines the cellular roles of actin. Here, we offer a perspective on the roles played by actin regulator molecules during the formation of the immunological synapse (IS) which is defined as the structure formed by the interaction between lymphocytes and antigen-presenting cells (APC). Proper actin dynamics at the IS are absolutely necessary for correct lymphocyte activation and alterations of such actin dynamics result in immune diseases.
%K actin
%K lymphocytes
%K immunological synapse
%K arp2/3
%K actin regulators
%U https://www.dovepress.com/actin-dynamics-at-the-immunological-synapse-peer-reviewed-article-CHC