%0 Journal Article
%T Articaine: a review of its use for local and regional anesthesia
%A Snoeck M
%J Local and Regional Anesthesia
%D 2012
%I Dove Medical Press
%R http://dx.doi.org/10.2147/LRA.S16682
%X rticaine: a review of its use for local and regional anesthesia Review (2000) Total Article Views Authors: Snoeck M Published Date June 2012 Volume 2012:5 Pages 23 - 33 DOI: http://dx.doi.org/10.2147/LRA.S16682 Received: 07 March 2012 Accepted: 19 April 2012 Published: 05 June 2012 Marc Snoeck Department of Anaesthesia, Canisius-Wilhelmina Hospital, Nijmegen, The Netherlands Abstract: Articaine is an intermediate-potency, short-acting amide local anesthetic with a fast metabolism due to an ester group in its structure. It is effective with local infiltration or peripheral nerve block in dentistry, when administered as a spinal, epidural, ocular, or regional nerve block, or when injected intravenously for regional anesthesia. In comparative trials, its clinical effects were not generally significantly different from those of other short-acting local anesthetics like lidocaine, prilocaine, and chloroprocaine, and there is no conclusive evidence demonstrating above-average neurotoxicity. Articaine proved to be suitable and safe for procedures requiring a short duration of action in which a fast onset of anesthesia is desired, eg, dental procedures and ambulatory spinal anesthesia, in normal and in special populations.
%K articaine
%K regional anesthesia
%K pharmacodynamics
%K pharmacokinetics
%K therapeutic use
%K tolerability
%K neurotoxicity
%U https://www.dovepress.com/articaine-a-review-of-its-use-for-local-and-regional-anesthesia-peer-reviewed-article-LRA