%0 Journal Article
%T Aqueous humor penetration of topical bimatoprost 0.01% and bimatoprost 0.03% in rabbits
%A Abayomi B Ogundele
%A Mark C Jasek
%J Clinical Ophthalmology
%D 2010
%I 
%R http://dx.doi.org/10.2147/OPTH.S15521
%X queous humor penetration of topical bimatoprost 0.01% and bimatoprost 0.03% in rabbits Original Research (3528) Total Article Views Authors: Abayomi B Ogundele, Mark C Jasek Published Date December 2010 Volume 2010:4 Pages 1447 - 1450 DOI: http://dx.doi.org/10.2147/OPTH.S15521 Abayomi B Ogundele, Mark C Jasek Alcon Research Ltd, Fort Worth, TX, USA Purpose: The purpose of this study was to compare the aqueous humor concentrations of bimatoprost acid after topical instillation in rabbits of bimatoprost ophthalmic solution 0.01% and bimatoprost ophthalmic solution 0.03%, two commercially available intraocular pressure-lowering medications. Methods: Male Dutch Belted rabbits were divided into two treatment groups (four rabbits/eight eyes per group): bimatoprost 0.01% and bimatoprost 0.03%. Thirty microliters (¦ÌL) of study medication was to pically instilled into both eyes of each animal. Thirty minutes and 90 minutes after instillation, aqueous humor samples were collected. These samples were analyzed by reverse-phase high-performance liquid chromatography for bimatoprost acid concentration. Results: Following a single topical ocular instillation, the bimatoprost 0.01% formulation had a lower mean aqueous humor concentration of bimatoprost acid than the bimatoprost 0.03% formulation at both 30 minutes (11.5 ¡À 2.1 ng/mL versus 37.8 ¡À 28.8 ng/mL; P = 0.17) and 90 minutes (20.8 ¡À 5.7 ng/mL versus 45.8 ¡À 14.3 ng/mL; P = 0.03) after topical instillation. Conclusions: Topical ocular instillation of bimatoprost 0.01% produced significantly lower bimatoprost acid concentration in the aqueous humor of rabbits than bimatoprost 0.03%, despite the 4-fold increase of benzalkonium chloride contained in bimatoprost 0.01%.
%K aqueous humor
%K benzalkonium chloride
%K bimatoprost
%K pharmacokinetics
%K preclinical
%K prostaglandin analog
%U https://www.dovepress.com/aqueous-humor-penetration-of-topical-bimatoprost-001-and-bimatoprost-0-peer-reviewed-article-OPTH