%0 Journal Article
%T Pattern-reversal visual-evoked potential in patients with occult macular dystrophy
%A Gen Hanazono
%A Hisao Ohde
%A Kei Shinoda
%A et al
%J Clinical Ophthalmology
%D 2010
%I 
%R http://dx.doi.org/10.2147/OPTH.S15088
%X ttern-reversal visual-evoked potential in patients with occult macular dystrophy Original Research (3775) Total Article Views Authors: Gen Hanazono, Hisao Ohde, Kei Shinoda, et al Published Date December 2010 Volume 2010:4 Pages 1515 - 1520 DOI: http://dx.doi.org/10.2147/OPTH.S15088 Gen Hanazono1,2, Hisao Ohde2,3, Kei Shinoda1,4, Kazushige Tsunoda1,2, Kazuo Tsubota2, Yozo Miyake1,5 1Department of Ophthalmology, National Institute of Sensory Organs, Tokyo, Japan; 2Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan; 3Kamoshita Eye Clinic, Tokyo, Japan; 4Department of Ophthalmology, Teikyo University School of Medicine, Tokyo, Japan; 5Aichi Medical School, Aichi, Japan Purpose: Occult macular dystrophy (OMD) is a hereditary retinal disease characterized by a normal fundus, normal full-field electroretinograms (ERGs), progressive decrease of visual acuity, and abnormal focal macular ERGs. The purpose of this study was to report pattern-reversal visual-evoked potential (pVEPs) findings in OMD patients. Patients and method: The pVEPs recorded from four patients with OMD (aged 42¨C61 years; 2 men and 2 women) were reviewed. The visual acuities ranged from 20/200 to 20/30. The amplitudes of the N-75 and P-100 (P2 amplitude) and the latency of the N-75 components (N1 latency) were analyzed. Results: The mean (¡ÀSD) P2 amplitude was 2.7 ¡À 1.9 ¦ÌV for the 5¡ä, 4.8 ¡À 2.9 ¦ÌV for the 10¡ä, 3.2 ¡À 2.1 ¦ÌV for the 20¡ä, and 4.4 ¡À 3.5 ¦ÌV for the 40¡ä checkerboard stimuli. The N1 latency was 122.2 ¡À 6.4 ms for the 5¡ä, 105.0 ¡À 11.5 ms for the 10¡ä, 97.7 ¡À 10.0 ms for the 20¡ä, and 91.0 ¡À 13.7 ms for the 40¡ä checkerboard stimuli. The mean P2 amplitude was reduced and the N1 latency was delayed in comparison with the laboratory standard for the Keio University Hospital. Conclusions: The delayed latency and reduced amplitude suggest a major contribution of the central cone pathway to the pVEPs.
%K occult macular dystrophy
%K visual-evoked potential
%K electroretinogram
%U https://www.dovepress.com/pattern-reversal-visual-evoked-potential-in-patients-with-occult-macul-peer-reviewed-article-OPTH