%0 Journal Article
%T Combined photodynamic therapy and intravitreal bevacizumab for idiopathic polypoidal choroidal vasculopathy: one-year follow-up
%A Mario R Romano
%A Ugo Cipollone
%A Francesco Semeraro
%A et al
%J Clinical Ophthalmology
%D 2010
%I 
%R http://dx.doi.org/10.2147/OPTH.S12577
%X mbined photodynamic therapy and intravitreal bevacizumab for idiopathic polypoidal choroidal vasculopathy: one-year follow-up Case Series (4822) Total Article Views Authors: Mario R Romano, Ugo Cipollone, Francesco Semeraro, et al Published Date October 2010 Volume 2010:4 Pages 1237 - 1241 DOI: http://dx.doi.org/10.2147/OPTH.S12577 Mario R Romano1, Ugo Cipollone2, Francesco Semeraro3, Michele Rinaldi4, Ciro Costagliola1 1Dipartimento di Scienze per la Salute, Universit¨¤ degli Studi del Molise, Campobasso; 2Dipartimento di Oftalmologia, Ospedale G Vietri, Larino, Campobasso; 3Clinica Oculistica, Universit¨¤ degli Studi di Brescia, Brescia; 4Clinica Oculistica, II Universit¨¤ degli Studi di Napoli, Napoli, Italy Objective: To report the efficacy and safety of combined photodynamic therapy (PDT) and intravitreal bevacizumab (IVB) injection in the treatment of idiopathic polypoidal choroidal vasculopathy (IPCV). Material and methods: A prospective case series of 10 eyes of 10 consecutive patients affected by IPCV with subfoveal involvement. PDT plus IVB (1.25 mg/0.05 mL) injection two weeks later was performed in all patients. Two adjunctive injections of bevacizumab were scheduled at four and eight weeks after the initial treatment. Best-corrected visual acuity (BCVA), fluorescein and indocyanine green angiographies, and optical coherence tomography were obtained at baseline, and at one, three, six, nine, and 12 months. Results: The combined treatment led to an improvement of both neurosensory detachment and pigmented epithelial detachment in all eyes, with a decrease of exudation and regression of macular thickness, which remained stable to the end of follow-up. However, BCVA remained stable over the 12 months of follow-up. Conclusion: These findings demonstrate that PDT/IVB combined therapy is able to achieve morphologic stabilization of the IPCV lesion, through a rapid decrease of macular thickness and regression of the size of polypoidal vascular lesion.
%K combined treatment
%K idiopathic polypoidal choroidal vasculopathy
%K age-related macular degeneration
%K intravitreal bevacizumab
%K photodynamic therapy
%U https://www.dovepress.com/combined-photodynamic-therapy-and-intravitreal-bevacizumab-for-idiopat-peer-reviewed-article-OPTH