%0 Journal Article
%T Association between assisted reproductive technology and advanced retinopathy of prematurity
%A RV Paul Chan
%A Yoshihiro Yonekawa
%A Margaux A Morrison
%A et al
%J Clinical Ophthalmology
%D 2010
%I 
%R http://dx.doi.org/10.2147/OPTH.S15587
%X ssociation between assisted reproductive technology and advanced retinopathy of prematurity Original Research (3715) Total Article Views Authors: RV Paul Chan, Yoshihiro Yonekawa, Margaux A Morrison, et al Published Date November 2010 Volume 2010:4 Pages 1385 - 1390 DOI: http://dx.doi.org/10.2147/OPTH.S15587 RV Paul Chan1, Yoshihiro Yonekawa1, Margaux A Morrison2,3, Grace Sun1, Ryan K Wong1, Jeffrey M Perlman4, Michael F Chiang5,6, Thomas C Lee7, M Elizabeth Hartnett3, Margaret M DeAngelis2,3 1Department of Ophthalmology, Weill Cornell Medical College, New York; 2Ocular Molecular Genetics Institute, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts; 3University of Utah School of Medicine, Moran Eye Center, Salt Lake City, Utah; 4Department of Pediatrics, Weill Cornell Medical College, New York; Departments of 5Ophthalmology and 6Biomedical Informatics, Columbia University College of Physicians and Surgeons, New York; 7The Vision Center, ChildrenĄ¯s Hospital Los Angeles, California, USA Purpose: To investigate the associations between assisted reproductive technology (ART) and severe retinopathy of prematurity (ROP) requiring treatment. Methods: Retrospective analyses of inborn preterm infants screened for severe ROP at the Weill Cornell Medical Center Neonatal Intensive Care Unit at the New York-Presbyterian Hospital by single factor logistic regression and multifactor models. Results: Of 399 ethnically diverse infants, 253 were conceived naturally and 146 by ART. Eight (3.16%) patients conceived naturally, and 11 (7.53%) with ART required laser treatment. In multifactor analyses, significant risks for severe ROP requiring treatment included both gestational age (odds ratio [OR] 0.34; 95% confidence interval [CI] 0.23¨C0.52; P< 0.001) and ART ([OR] 4.70; [CI], 1.52¨C4.57; P = 0.007). Conclusions: ART is associated with severe ROP requiring treatment in this cohort. This is the first report that demonstrates a statistically significant association between ART and severe ROP requiring treatment in infants in the US.
%K retinopathy of prematurity
%K low birth rate
%K blindness
%K assisted reproductive technology
%U https://www.dovepress.com/association-between-assisted-reproductive-technology-and-advanced-reti-peer-reviewed-article-OPTH