%0 Journal Article
%T Concepts and practices used to develop functional PLGA-based nanoparticulate systems
%A Sah H
%A Thoma LA
%A Desu HR
%A Sah E
%A Wood GC
%J International Journal of Nanomedicine
%D 2013
%I 
%R http://dx.doi.org/10.2147/IJN.S40579
%X ncepts and practices used to develop functional PLGA-based nanoparticulate systems Review (1669) Total Article Views Authors: Sah H, Thoma LA, Desu HR, Sah E, Wood GC Published Date February 2013 Volume 2013:8 Pages 747 - 765 DOI: http://dx.doi.org/10.2147/IJN.S40579 Received: 29 November 2012 Accepted: 11 January 2013 Published: 21 February 2013 Hongkee Sah,1,2 Laura A Thoma,2 Hari R Desu,2 Edel Sah,3 George C Wood2 1College of Pharmacy, Ewha Womans University, Sedaemun-gu, Seoul, South Korea; 2College of Pharmacy, The University of Tennessee Health Science Center, Memphis, TN, USA; 3College of Science, University of Notre Dame, Notre Dame, IN, USA Abstract: The functionality of bare polylactide-co-glycolide (PLGA) nanoparticles is limited to drug depot or drug solubilization in their hard cores. They have inherent weaknesses as a drug-delivery system. For instance, when administered intravenously, the nanoparticles undergo rapid clearance from systemic circulation before reaching the site of action. Furthermore, plain PLGA nanoparticles cannot distinguish between different cell types. Recent research shows that surface functionalization of nanoparticles and development of new nanoparticulate dosage forms help overcome these delivery challenges and improve in-vivo performance. Immense research efforts have propelled the development of diverse functional PLGA-based nanoparticulate delivery systems. Representative examples include PEGylated micelles/nanoparticles (PEG, polyethylene glycol), polyplexes, polymersomes, core-shell¨Ctype lipid-PLGA hybrids, cell-PLGA hybrids, receptor-specific ligand-PLGA conjugates, and theranostics. Each PLGA-based nanoparticulate dosage form has specific features that distinguish it from other nanoparticulate systems. This review focuses on fundamental concepts and practices that are used in the development of various functional nanoparticulate dosage forms. We describe how the attributes of these functional nanoparticulate forms might contribute to achievement of desired therapeutic effects that are not attainable using conventional therapies. Functional PLGA-based nanoparticulate systems are expected to deliver chemotherapeutic, diagnostic, and imaging agents in a highly selective and effective manner.
%K nanoparticulate dosage forms
%K nanoparticles
%K polylactide-co-glycolide
%K functionality
%U https://www.dovepress.com/concepts-and-practices-used-to-develop-functional-plga-based-nanoparti-peer-reviewed-article-IJN