%0 Journal Article
%T Cubic phase nanoparticles for sustained release of ibuprofen formulation characterization and enhanced bioavailability study
%A Dian L
%A Yang Z
%A Li F
%A Wang Z
%A Pan X
%A Peng X
%A Huang X
%A Guo Z
%A Quan G
%A Shi X
%A Chen B
%A Li G
%A Wu C
%J International Journal of Nanomedicine
%D 2013
%I 
%R http://dx.doi.org/10.2147/IJN.S40547
%X bic phase nanoparticles for sustained release of ibuprofen formulation characterization and enhanced bioavailability study Original Research (1027) Total Article Views Authors: Dian L, Yang Z, Li F, Wang Z, Pan X, Peng X, Huang X, Guo Z, Quan G, Shi X, Chen B, Li G, Wu C Published Date February 2013 Volume 2013:8 Pages 845 - 854 DOI: http://dx.doi.org/10.2147/IJN.S40547 Received: 20 November 2012 Accepted: 01 January 2013 Published: 26 February 2013 Linghui Dian,1,2,* Zhiwen Yang,3,* Feng Li,1 Zhouhua Wang,1 Xin Pan,1 Xinsheng Peng,2 Xintian Huang,1 Zhefei Guo,1 Guilan Quan,1 Xuan Shi,1 Bao Chen,1 Ge Li,4 Chuanbin Wu1,4 1School of Pharmaceutical Sciences, Sun Yat-Sen University, University Town, Guangzhou, People¡¯s Republic of China; 2School of Pharmaceutical Sciences, Guangdong Medical College, Dongguan, People¡¯s Republic of China; 3Department of Gastroenterology, Songjiang Branch of the Affiliated First People¡¯s Hospital of Shanghai Jiaotong University, Shanghai, People¡¯s Republic of China; 4Guangdong Research Center for Drug Delivery Systems, Guangzhou, People¡¯s Republic of China *These authors contributed equally to this work Abstract: In order to improve the oral bioavailability of ibuprofen, ibuprofen-loaded cubic nanoparticles were prepared as a delivery system for aqueous formulations. The cubic inner structure was verified by cryogenic transmission electron microscopy. With an encapsulation efficiency greater than 85%, the ibuprofen-loaded cubic nanoparticles had a narrow size distribution around a mean size of 238 nm. Differential scanning calorimetry and X-ray diffraction determined that ibuprofen was in an amorphous and molecular form within the lipid matrix. The in vitro release of ibuprofen from cubic nanoparticles was greater than 80% at 24 hours, showing sustained characteristics. The pharmacokinetic study in beagle dogs showed improved absorption of ibuprofen from cubic nanoparticles compared to that of pure ibuprofen, with evidence of a longer half-life and a relative oral bioavailability of 222% (P < 0.05). The ibuprofen-loaded cubic nanoparticles provide a promising carrier candidate with an efficient drug delivery for therapeutic treatment.
%K ibuprofen
%K cubic nanoparticles
%K oral drug delivery
%K bioavailability
%U https://www.dovepress.com/cubic-phase-nanoparticles-for-sustained-release-of-ibuprofen-formulati-peer-reviewed-article-IJN