%0 Journal Article
%T Intracellular delivery of doxorubicin encapsulated in novel pH-responsive chitosan/heparin nanocapsules
%A Thomas MB
%A Radhakrishnan K
%A Gnanadhas DP
%A Chakravortty D
%A Raichur AM
%J International Journal of Nanomedicine
%D 2013
%I 
%R http://dx.doi.org/10.2147/IJN.S37737
%X tracellular delivery of doxorubicin encapsulated in novel pH-responsive chitosan/heparin nanocapsules Original Research (1212) Total Article Views Authors: Thomas MB, Radhakrishnan K, Gnanadhas DP, Chakravortty D, Raichur AM Published Date January 2013 Volume 2013:8 Pages 267 - 273 DOI: http://dx.doi.org/10.2147/IJN.S37737 Received: 05 September 2012 Accepted: 22 October 2012 Published: 11 January 2013 Midhun B Thomas,1,* Krishna Radhakrishnan,1,* Divya P Gnanadhas,2,* Dipshikha Chakravortty,2 Ashok M Raichur1,3 1Department of Materials Engineering, 2Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India; 3Department of Applied Chemistry, University of Johannesburg, Doornfontein, South Africa *These authors contributed equally to this work Abstract: A novel polyelectrolyte nanocapsule system composed of biopolymers, chitosan and heparin has been fabricated by the layer-by-layer technique on silica nanoparticles followed by dissolution of the silica core. The nanocapsules were of the size range 200 ¡À 20 nm and loaded with the positively charged anticancer drug doxorubicin with an efficiency of 89%. The loading of the drug into the capsule happens by virtue of the pH-responsive property of the capsule wall, which is determined by the pKa of the polyelectrolytes. As the pH is varied, about 64% of the drug is released in acidic pH while 77% is released in neutral pH. The biocompatibility, efficiency of drug loading, and enhanced bioavailability of the capsule system was confirmed by MTT assay and in vivo biodistribution studies.
%K drug delivery
%K layer-by-layer
%K electrostatic interaction
%K biocompatible
%U https://www.dovepress.com/intracellular-delivery-of-doxorubicin-encapsulated-in-novel-ph-respons-peer-reviewed-article-IJN