%0 Journal Article
%T Composite scaffolds of mesoporous bioactive glass and polyamide for bone repair
%A Su J
%A Cao L
%A Yu B
%A Song S
%A Liu X
%A Wang Z
%A Li M
%J International Journal of Nanomedicine
%D 2012
%I 
%R http://dx.doi.org/10.2147/IJN.S29819
%X mposite scaffolds of mesoporous bioactive glass and polyamide for bone repair Original Research (9300) Total Article Views Authors: Su J, Cao L, Yu B, Song S, Liu X, Wang Z, Li M Published Date May 2012 Volume 2012:7 Pages 2547 - 2555 DOI: http://dx.doi.org/10.2147/IJN.S29819 Received: 09 January 2012 Accepted: 17 February 2012 Published: 21 May 2012 Jiacan Su, Liehu Cao, Baoqing Yu, Shaojun Song, Xinwei Liu, Zhiwei Wang, Ming Li Department of Orthopedics, Changhai Hospital, Second Military Medical University, Shanghai, China Abstract: A bone-implanted porous scaffold of mesoporous bioglass/polyamide composite (m-BPC) was fabricated, and its biological properties were investigated. The results indicate that the m-BPC scaffold contained open and interconnected macropores ranging 400¨C500 ¦Ìm, and exhibited a porosity of 76%. The attachment ratio of MG-63 cells on m-BPC was higher than polyamide scaffolds at 4 hours, and the cells with normal phenotype extended well when cultured with m-BPC and polyamide scaffolds. When the m-BPC scaffolds were implanted into bone defects of rabbit thighbone, histological evaluation confirmed that the m-BPC scaffolds exhibited excellent biocompatibility and osteoconductivity, and more effective osteogenesis than the polyamide scaffolds in vivo. The results indicate that the m-BPC scaffolds improved the efficiency of new bone regeneration and, thus, have clinical potential for bone repair.
%K mesoporous bioglass
%K polyamide
%K composite scaffolds
%K biocompatibility
%K bone repair
%U https://www.dovepress.com/composite-scaffolds-of-mesoporous-bioactive-glass-and-polyamide-for-bo-peer-reviewed-article-IJN