%0 Journal Article
%T Co-nanoencapsulation of magnetic nanoparticles and selol for breast tumor treatment: in vitro evaluation of cytotoxicity and magnetohyperthermia efficacy
%A Estevanato LC
%A Da Silva JR
%A Falqueiro AM
%A Mosiniewicz-Szablewska E
%A Suchocki P
%A Tedesco AC
%A Morais PC
%A Lacava ZG
%J International Journal of Nanomedicine
%D 2012
%I 
%R http://dx.doi.org/10.2147/IJN.S35279
%X -nanoencapsulation of magnetic nanoparticles and selol for breast tumor treatment: in vitro evaluation of cytotoxicity and magnetohyperthermia efficacy Original Research (1917) Total Article Views Authors: Estevanato LC, Da Silva JR, Falqueiro AM, Mosiniewicz-Szablewska E, Suchocki P, Tedesco AC, Morais PC, Lacava ZG Published Date October 2012 Volume 2012:7 Pages 5287 - 5299 DOI: http://dx.doi.org/10.2147/IJN.S35279 Received: 22 June 2012 Accepted: 25 July 2012 Published: 05 October 2012 Luciana LC Estevanato,1 Jaqueline R Da Silva,1 Andr¨¦ M Falqueiro,2 Ewa Mosiniewicz-Szablewska,3 Piotr Suchocki,4,5 Ant nio C Tedesco,2 Paulo C Morais,6 Zulmira GM Lacava1 1Instituto de Ci¨ºncias Biol¨®gicas, Universidade de Bras¨ªlia, Bras¨ªlia DF, Brazil; 2Departamento de Qu¨ªmica, Laborat¨®rio de Fotobiologia e Fotomedicina, Faculdade de Filosofia, Ci¨ºncias e Letras de Ribeir o Preto, Universidade de S o Paulo, Ribeir o Preto SP, Brazil; 3Institute of Physics, Polish Academy of Sciences, Warsaw, Poland; 4Department of Drug Analysis, Warsaw Medical University, Warsaw, Poland; 5Department of Pharmaceutical Chemistry, National Medicines Institute, Warsaw, Poland; 6Instituto de F¨ªsica, Universidade de Bras¨ªlia, Bras¨ªlia DF, Brazil Abstract: Antitumor activities have been described in selol, a hydrophobic mixture of molecules containing selenium in their structure, and also in maghemite magnetic nanoparticles (MNPs). Both selol and MNPs were co-encapsulated within poly(lactic-co-glycolic acid) (PLGA) nanocapsules for therapeutic purposes. The PLGA-nanocapsules loaded with MNPs and selol were labeled MSE-NC and characterized by transmission and scanning electron microscopy, electrophoretic mobility, photon correlation spectroscopy, presenting a monodisperse profile, and positive charge. The antitumor effect of MSE-NC was evaluated using normal (MCF-10A) and neoplastic (4T1 and MCF-7) breast cell lines. Nanocapsules containing only MNPs or selol were used as control. MTT assay showed that the cytotoxicity induced by MSE-NC was dose and time dependent. Normal cells were less affected than tumor cells. Cell death occurred mainly by apoptosis. Further exposure of MSE-NC treated neoplastic breast cells to an alternating magnetic field increased the antitumor effect of MSE-NC. It was concluded that selol-loaded magnetic PLGA-nanocapsules (MSE-NC) represent an effective magnetic material platform to promote magnetohyperthermia and thus a potential system for antitumor therapy.
%K PLGA-nanocapsule
%K cancer
%K maghemite nanoparticle
%K MTT
%K drug delivery
%K selenium
%U https://www.dovepress.com/co-nanoencapsulation-of-magnetic-nanoparticles-and-selol-for-breast-tu-peer-reviewed-article-IJN