%0 Journal Article
%T An update on the management of glandular fever (infectious mononucleosis) and its sequelae caused by Epstein¨CBarr virus (HHV-4): new and emerging treatment strategies
%A A Martin Lerner
%A Safedin H Beqaj
%A Ken Gill
%A et al
%J Virus Adaptation and Treatment
%D 2010
%I Dove Medical Press
%R http://dx.doi.org/10.2147/VAAT.S6749
%X n update on the management of glandular fever (infectious mononucleosis) and its sequelae caused by Epstein¨CBarr virus (HHV-4): new and emerging treatment strategies Review (5167) Total Article Views Authors: A Martin Lerner, Safedin H Beqaj, Ken Gill, et al Published Date September 2010 Volume 2010:2 Pages 135 - 145 DOI: http://dx.doi.org/10.2147/VAAT.S6749 A Martin Lerner1, Safedin H Beqaj2, Ken Gill3, James Edington3, James T Fitzgerald4, Robert G Deeter5 1Department of Medicine, William Beaumont Hospital, Royal Oak, MI, USA; 2DCL Medical Laboratories, Indianapolis, IN, USA; 3The Dr A Martin Lerner, Chronic Fatigue Syndrome Foundation, Beverly Hills, MI, USA; 4Department of Medical Education, University of Michigan, Medical School, Ann Arbor, MI, USA; 5Hematology-Oncology, Global Health Economics, Amgen Inc, Thousand Oaks, CA, USA Purpose: Beginning in 1993 at a single chronic fatigue syndrome (CFS) treatment center, we began studies that demonstrate Epstein¨CBarr virus (EBV) nonpermissive replication. In the most recent study performed, EBV nonpermissive replication is the cause of 28.3% of 106 consecutive CFS cases, and is etiologic with human cytomegalovirus (HCMV) and/or human herpes virus 6 (HHV-6) as a coinfection in an additional 52.8% of CFS cases. Therefore, EBV is causally involved in 81% of cases of CFS. Further, EBV CFS is effectively treated with long-term valacyclovir. Coinfection HCMV and HHV-6 CFS requires valganciclovir with valacyclovir. Patients and results: The validated Energy Index Point Score  (EIPS ) monitors severity of CFS illness and its recovery. A specific CFS diagnostic panel identifies EBV CFS subsets. Four separate EBV CFS therapeutic studies of several hundred CFS patients describe valacyclovir administration and long-term patient recovery. With valacyclovir, serum EBV titers (EBV, early antigen (diffuse); EBV, viral capsid antigen, immunoglobulin M); 24-hour electrocardiography Holter monitors; and cardiac dynamic studies improve. Conclusion: Nonpermissive EBV infection is causal in a significant proportion of CFS cases. EBV CFS is safely and effectively treated with long-term valacyclovir.
%K valacyclovir treatment
%K chronic fatigue syndrome
%K Epstein¨CBarr virus
%K EIPS
%K Energy Index Point Score
%U https://www.dovepress.com/an-update-on-the-management-of-glandular-fever-infectious-mononucleosi-peer-reviewed-article-VAAT