%0 Journal Article
%T Treatment with budesonide/formoterol pressurized metered-dose inhaler in patients with asthma: a focus on patient-reported outcomes
%A Richard D O'Connor
%J Patient Related Outcome Measures
%D 2011
%I Dove Medical Press
%R http://dx.doi.org/10.2147/PROM.S16159
%X eatment with budesonide/formoterol pressurized metered-dose inhaler in patients with asthma: a focus on patient-reported outcomes Review (3412) Total Article Views Authors: Richard D O'Connor Published Date January 2011 Volume 2011:2 Pages 41 - 55 DOI: http://dx.doi.org/10.2147/PROM.S16159 Richard D O'Connor Sharp Rees-Stealy Medical Group, San Diego, CA, USA Abstract: In the United States, budesonide/formoterol pressurized metered-dose inhaler (pMDI) is approved for treatment of asthma in patients aged ¡Ư12 years whose asthma is not adequately controlled with an inhaled corticosteroid (ICS) or whose disease severity clearly warrants treatment with an ICS and a long-acting ¦Â2-adrenergic agonist. This article reviews studies of budesonide/formoterol pMDI in patients with persistent asthma, with a particular focus on patient-reported outcomes (eg, perceived onset of effect, patient satisfaction with treatment, health-related quality of life [HRQL], global assessments, sleep quality and quantity), as these measures reflect patient perceptions of asthma control and disease burden. A search of PubMed and respiratory meetings was performed to identify relevant studies. In two pivotal budesonide/formoterol pMDI studies in adolescents and adults, greater efficacy and similar tolerability were shown with budesonide/formoterol pMDI 160/9 ¦̀g and 320/9 ¦̀g twice daily versus its monocomponents or placebo. In those studies, improvements in HRQL, patient satisfaction, global assessments of asthma control, and quality of sleep also favored budesonide/formoterol pMDI compared with one or both of its monocomponents or placebo. Budesonide/formoterol pMDI has a rapid onset of effect (within 15 minutes) that patients can feel, an attribute that may have benefits for treatment adherence. In summary, budesonide/formoterol pMDI is effective and well tolerated and has additional therapeutic benefits that may be important from the patient¡¯s perspective.
%K budesonide
%K formoterol
%K patient-reported outcomes
%K efficacy
%K tolerability
%K onset of effect
%U https://www.dovepress.com/treatment-with-budesonideformoterol-pressurized-metered-dose-inhaler-i-peer-reviewed-article-PROM