%0 Journal Article
%T Long-term effectiveness and safety of sirolimus drug-eluting stents
%A Bikkina M
%A Koneru J
%J Medical Devices: Evidence and Research
%D 2011
%I Dove Medical Press
%R http://dx.doi.org/10.2147/MDER.S11749
%X ng-term effectiveness and safety of sirolimus drug-eluting stents Review (2485) Total Article Views Authors: Bikkina M, Koneru J Published Date August 2011 Volume 2011:4 Pages 117 - 124 DOI: http://dx.doi.org/10.2147/MDER.S11749 Mahesh Bikkina, Jayanth Koneru St Joseph Regional Medical Center, Paterson, Seton Hall University, NJ, USA Abstract: The root cause of coronary artery disease is atherosclerosis, ie, intraluminal narrowing (stenosis) of the arteries that supply blood to tissues of the heart. The introduction of the drug-eluting stent over the past decade has revolutionized the field of interventional cardiology. It is used extensively in clinical practice for the treatment of coronary artery disease. The first drug-eluting stent to receive US Food and Drug Administration approval was the sirolimus-eluting stent. Recently, two other stent analogs of sirolimus were approved, ie, the zotarolimus-eluting stent and the everolimus-eluting stent. However, concern has arisen in recent years about the long-term safety and efficacy of drug-eluting stents, due to the occurrence of late adverse clinical events, such as stent thrombosis. This review focuses on clinical studies that have been performed with the sirolimus-eluting stent or its analogs. We discuss the pharmacology, safety, and various therapeutic options that exist when choosing stents for coronary artery disease. Our aim is to provide a thorough review of the long-term efficacy and safety of sirolimus drug-eluting stents, and also to discuss currently approved and promising investigational drug-eluting stents, in an effort to provide insight into how these stents are currently evolving and generate further investigation in this area.
%K drug-eluting stent
%K long-term safety
%K sirolimus
%U https://www.dovepress.com/long-term-effectiveness-and-safety-of-sirolimus-drug-eluting-stents-peer-reviewed-article-MDER