%0 Journal Article
%T Daptomycin approved in Japan for the treatment of methicillin-resistant Staphylococcus aureus
%A Hagihara M
%A Umemura T
%A Mori T
%A Mikamo H
%J Therapeutics and Clinical Risk Management
%D 2012
%I 
%R http://dx.doi.org/10.2147/TCRM.S23875
%X ptomycin approved in Japan for the treatment of methicillin-resistant Staphylococcus aureus Review (2778) Total Article Views Authors: Hagihara M, Umemura T, Mori T, Mikamo H Published Date February 2012 Volume 2012:8 Pages 79 - 86 DOI: http://dx.doi.org/10.2147/TCRM.S23875 Received: 10 December 2011 Accepted: 17 January 2012 Published: 17 February 2012 Mao Hagihara1, Takumi Umemura1, Takeshi Mori1,2, Hiroshige Mikamo1 1Department of Infection Control and Prevention, Aichi Medical University School of Medicine, Nagakute, Aichi, Japan; 2Division of Pharmaceutical Science, Faculty of Pharmacy, Meijo University, Nagoya, Aichi, Japan Abstract: Daptomycin is a lipoglycopeptide antibacterial drug that is rapidly bactericidal for methicillin-resistant Staphylococcus aureus (MRSA) infection and has antibiotic activity against a wide range of Gram-positive organisms. It has been approved by the Ministry of Health, Labor and Welfare in Japan for the treatment for bacteremia, right-sided endocarditis, and skin and skin-structure infections, such as necrotizing fasciitis, due to MRSA on the basis of a Phase III trial conducted in Japan since July, 2011. In Japanese Phase I and III trials, daptomycin therapy given at 4 mg/kg and 6 mg/kg once per day was well tolerated and effective as standard therapy for the treatment of acute bacterial skin and skin-structure infections and bacteremia caused by MRSA, but side effects remain to be evaluated in large-scale trials.
%K daptomycin
%K methicillin-resistant Staphylococcus aureus (MRSA)
%K Japan
%U https://www.dovepress.com/daptomycin-approved-in-japan-for-the-treatment-of-methicillin-resistan-peer-reviewed-article-TCRM