%0 Journal Article
%T ¦Ã¦Ä T cells and IL-17/IL-17R signaling axis in CNS inflammation
%A Jayasri Das Sarma
%J International Journal of Interferon, Cytokine and Mediator Research
%D 2010
%I Dove Medical Press
%R http://dx.doi.org/10.2147/IJICMR.S7066
%X ells and IL-17/IL-17R signaling axis in CNS inflammation Review (3193) Total Article Views Authors: Jayasri Das Sarma Published Date November 2010 Volume 2010:2 Pages 149 - 155 DOI: http://dx.doi.org/10.2147/IJICMR.S7066 Jayasri Das Sarma Department of Biological Sciences, Indian Institute of Science Education and Research ¨C Kolkata, Mohanpur, Nadia, West Bengal, India Abstract: Lymphocytes expressing ¦Ã¦Ä T-cell receptors constitute an entire system of functionally specialized subsets that have been implicated in the regulation of immune responses, including responses to pathogens and allergens, and in tissue repair. ¦Ã¦Ä T cells represent a small subpopulation of T cells that, unlike a¦Â T cells, function more as cells of the innate immune system. ¦Ã¦Ä T cells are known to mediate the production of inflammatory cytokines, including interferon-¦Ã, tumor necrosis factor-a, and interleukin (IL)-17, and thus enable the activation of other subsets of infiltrating effector cells. However, not much attention was paid to ¦Ã¦Ä T cells until the recent discovery of a distinct CD4+ T helper (TH) cell, TH17 cell. CD4+ T cells, upon activation and expansion, develop into different TH-cell subsets with different cytokine profiles and distinct effector functions. T cells were earlier divided into TH1 or TH2 cells, depending on the cytokines they produce. A third subset of IL-17-producing effector TH cells, called TH17 cells, has been discovered and characterized recently. Since then the literature on IL-17-producing cells has grown steadily, and several studies have focused on ¦Ã¦Ä T cells. Cytokine-mediated modulation of central nervous system (CNS) inflammatory diseases by ¦Ã¦Ä T cells in humans or in animal models is currently the subject of many studies. IL-17 and its receptor IL-17R have been implicated in the pathogenesis of immune-mediated CNS diseases, and attention has been paid to understand the mechanisms by which IL-17 cytokines and it receptor (IL-17R) family mediate the effects at a molecular level. This article reviews the studies that cover earlier aspects of ¦Ã¦Ä T cell/IL-17 biology and the new dimension of ¦Ã¦Ä T cells, IL-17, and IL-17/IL-17R signaling axis in CNS inflammation. Understanding the role of ¦Ã¦Ä T cells, IL-17, and IL-17/IL-17R signaling axis in infection and immunity could open a new avenue for immunomodulation.
%K cytokine
%K ¦Ã¦Ä T cells
%K TH17 cells
%K IL-17
%K IL-17R
%K multiple sclerosis
%K EAE
%K autoimmunity
%K CNS
%K viral infection
%K virus-induced demyelination
%U https://www.dovepress.com/gammadelta-t-cells-and-il-17il-17r-signaling-axis-in-cns-inflammation-peer-reviewed-article-IJICMR