%0 Journal Article
%T Topical nonsteroidal anti-inflammatory drugs for management of osteoarthritis in long-term care patients
%A Argoff CE
%A Gloth FM
%J Therapeutics and Clinical Risk Management
%D 2011
%I 
%R http://dx.doi.org/10.2147/TCRM.S24458
%X pical nonsteroidal anti-inflammatory drugs for management of osteoarthritis in long-term care patients Review (4318) Total Article Views Authors: Argoff CE, Gloth FM Published Date September 2011 Volume 2011:7 Pages 393 - 399 DOI: http://dx.doi.org/10.2147/TCRM.S24458 Charles E Argoff1, F Michael Gloth2 1Albany Medical College and Comprehensive Pain Center, Albany Medical Center, Albany, NY, USA; 2Johns Hopkins University School of Medicine, Baltimore, MD, USA Abstract: Osteoarthritis is common in patients ¡Ý65 years of age. Although nonsteroidal anti-inflammatory drugs (NSAIDs) are often prescribed for osteoarthritis pain, they pose age-related cardiovascular, renal, and gastrointestinal risks. Two topical NSAIDs, diclofenac sodium 1% gel (DSG) and diclofenac sodium 1.5% in 45.5% dimethylsulfoxide solution (D-DMSO), are approved in the US for the treatment of osteoarthritis pain. Topical NSAIDs have shown efficacy and safety in knee (DSG, D-DMSO) and hand (DSG) osteoarthritis. Analyses of data from randomized controlled trials of DSG in hand and knee osteoarthritis demonstrate significant improvement of pain and function in both younger patients (<65 years) and older patients (¡Ý65 years) and suggest good safety and tolerability. However, long-term safety data in older patients are limited. Topical NSAIDs can ease medication administration and help address barriers to pain management in older patients, such as taking multiple medications and inability to swallow, and are a valuable option for long-term care providers.
%K nonsteroidal anti-inflammatory drugs
%K long-term care
%K nursing homes
%K chronic pain
%K topical analgesics
%U https://www.dovepress.com/topical-nonsteroidal-anti-inflammatory-drugs-for-management-of-osteoar-peer-reviewed-article-TCRM