%0 Journal Article
%T Hypertension in response to IL-6 during pregnancy: role of AT1-receptor activation
%A LaMarca B
%A Speed J
%A Ray LF
%A Cockrell K
%A Wallukat G
%A Dechend R
%A Granger J
%J International Journal of Interferon, Cytokine and Mediator Research
%D 2011
%I Dove Medical Press
%R http://dx.doi.org/10.2147/IJICMR.S22329
%X tension in response to IL-6 during pregnancy: role of AT1-receptor activation Original Research (1731) Total Article Views Authors: LaMarca B, Speed J, Ray LF, Cockrell K, Wallukat G, Dechend R, Granger J Published Date November 2011 Volume 2011:3 Pages 65 - 70 DOI: http://dx.doi.org/10.2147/IJICMR.S22329 Babbette LaMarca1, Joshua Speed1, Lillian Fournier Ray1, Kathy Cockrell1, Gerd Wallukat2, Ralf Dechend2, Joey Granger1 1Departments of Obstetrics and Gynecology/Physiology, Center for Excellence in Renal and Cardiovascular Research, University of Mississippi Medical Center, Jackson, MS, USA; 2HELIOS Clinic, Charite, Campus-Buch and Max-Delbrueck Center, Berlin, Germany Background: Increases in interleukin 6 (IL-6) and agonistic autoantibodies to the angiotensin II type 1 receptor (AT1-AA) are proposed to be important links between placental ischemia and hypertension in preeclampsia. Methods: The purpose of this study was to determine whether IL-6 (5 ng/day), infused into normal pregnant (NP) rats, increased mean arterial pressure (MAP) and AT1-AA. MAP was analyzed in the presence and absence of an angiotensin type 1 receptor (AT1R) antagonist, losartan, L. Results: MAP and AT1-AA increased from 102 ¡À 2 to 118 ¡À 4 mmHg and 0.7 ¡À 0.3 NP to 14.1 ¡À 1.4 chronotropic units with chronic IL-6 infusion. MAP responses to IL-6 were abolished in losartan pretreated rats (85 ¡À 4 in NP + L vs 85 ¡À 3 mmHg in IL-6 + L). Conclusion: These data indicate that IL-6 stimulates AT1-AA and that activation of the AT1R mediates IL-6 induced hypertension during pregnancy.
%K cytokines
%K pregnancy
%K hypertension
%K renin angiotensin system
%K inflammation
%U https://www.dovepress.com/hypertension-in-response-to-il-6-during-pregnancy-role-of-at1-receptor-peer-reviewed-article-IJICMR