%0 Journal Article
%T Topical niacinamide 4% and desonide 0.05% for treatment of axillary hyperpigmentation: a randomized, double-blind, placebo-controlled study
%A Castanedo-Cazares JP
%A L¨¢rraga-Pi ones G
%A Ehnis-P¨¦rez A
%A Fuentes-Ahumada C
%A Oros-Ovalle C
%A Smoller BR
%A Torres-Alvarez B
%J Clinical, Cosmetic and Investigational Dermatology
%D 2013
%I 
%R http://dx.doi.org/10.2147/CCID.S39246
%X pical niacinamide 4% and desonide 0.05% for treatment of axillary hyperpigmentation: a randomized, double-blind, placebo-controlled study Original Research (1412) Total Article Views Authors: Castanedo-Cazares JP, L¨¢rraga-Pi ones G, Ehnis-P¨¦rez A, Fuentes-Ahumada C, Oros-Ovalle C, Smoller BR, Torres-Alvarez B Published Date January 2013 Volume 2013:6 Pages 29 - 36 DOI: http://dx.doi.org/10.2147/CCID.S39246 Received: 16 October 2012 Accepted: 27 November 2012 Published: 14 January 2013 Juan Pablo Castanedo-Cazares,1 Gabryela L¨¢rraga-Pi ones,1 Adriana Ehnis-P¨¦rez,1 Cornelia Fuentes-Ahumada,1 Cuauhtemoc Oros-Ovalle,2 Bruce R Smoller,3 Bertha Torres-¨¢lvarez1 1Department of Dermatology, 2Department of Pathology, Hospital Central Dr Ignacio Morones Prieto, Universidad Aut¨®noma de San Luis Potos¨ª, M¨¦xico; 3Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AK, USA Background: Axillary hyperpigmentation is a frequent cause of cosmetic consultations in dark-skinned women from tropical areas, including Latin America. Currently, there is no widely accepted treatment for the disorder, but it is usually treated with bleaching agents because it is considered a variant of inflammatory hyperpigmentation. The purpose of this study was to assess the efficacy of niacinamide 4% and desonide 0.05% emulsions compared with placebo in the treatment of axillary hyperpigmentation. Methods: Twenty-four women aged 19¨C27 years with hyperpigmented axillae (phototype III¨CV) were randomly assigned to receive the study treatments in the axillary region. Improvement was assessed at baseline, then clinically and by colorimetry 9 weeks later. Quantitative evaluation including melanin, inflammatory infiltrates, NKI/Beteb, CD1a, CD68, and collagen type IV content was performed by histochemistry and immunohistochemistry, assisted by computerized morphometric analysis. Results: Both niacinamide and desonide induced significant colorimetric improvement compared with placebo; however, desonide showed a better depigmenting effect than niacinamide. A good to excellent response was achieved in 24% of cases for niacinamide, 30% for desonide, and 6% for placebo. We observed a marked disruption of the basal membrane in axillary hyperpigmentation and an inflammatory infiltrate that improved after treatment. Decreased pigmentation in the desonide-treated axillae was associated with recovery of disruption at the basal membrane. Conclusion: Niacinamide and desonide showed depigmenting properties in women with axillary hyperpigmentation. These findings may be explained by their antimelanogenic and anti-inflammatory properties, respectively.
%K post-inflammatory hyperpigmentation
%K niacinamide
%K desonide
%U https://www.dovepress.com/topical-niacinamide-4-and-desonide-005-for-treatment-of-axillary-hyper-peer-reviewed-article-CCID