%0 Journal Article %T Hematopoietic stem cell transplantation %A Eleftheria Hatzimichael %A Mark Tuthill %J Stem Cells and Cloning: Advances and Applications %D 2010 %I Dove Medical Press %R http://dx.doi.org/10.2147/SCCAA.S6815 %X topoietic stem cell transplantation Review (5794) Total Article Views Authors: Eleftheria Hatzimichael, Mark Tuthill Published Date August 2010 Volume 2010:3 Pages 105 - 117 DOI: http://dx.doi.org/10.2147/SCCAA.S6815 Eleftheria Hatzimichael1, Mark Tuthill2 1Department of Haematology, Medical School of Ioannina, University of Ioannina, Ioannina, Greece; 2Department of Medical Oncology, Hammersmith Hospital, Imperial College National Health Service Trust, London, UK Abstract: More than 25,000 hematopoietic stem cell transplantations (HSCTs) are performed each year for the treatment of lymphoma, leukemia, immune-deficiency illnesses, congenital metabolic defects, hemoglobinopathies, and myelodysplastic and myeloproliferative syndromes. Before transplantation, patients receive intensive myeloablative chemoradiotherapy followed by stem cell ¡°rescue.¡± Autologous HSCT is performed using the patient¡¯s own hematopoietic stem cells, which are harvested before transplantation and reinfused after myeloablation. Allogeneic HSCT uses human leukocyte antigen (HLA)-matched stem cells derived from a donor. Survival after allogeneic transplantation depends on donor¨Crecipient matching, the graft-versus-host response, and the development of a graft versus leukemia effect. This article reviews the biology of stem cells, clinical efficacy of HSCT, transplantation procedures, and potential complications. %K hematopoietic stem cell transplantation %K complications %U https://www.dovepress.com/hematopoietic-stem-cell-transplantation-peer-reviewed-article-SCCAA