%0 Journal Article %T Lactose intolerance: diagnosis, genetic, and clinical factors %A Mattar R %A Mazo DF %A Carrilho FJ %J Clinical and Experimental Gastroenterology %D 2012 %I Dove Medical Press %R http://dx.doi.org/10.2147/CEG.S32368 %X ctose intolerance: diagnosis, genetic, and clinical factors Review (4033) Total Article Views Authors: Mattar R, Mazo DF, Carrilho FJ Published Date July 2012 Volume 2012:5 Pages 113 - 121 DOI: http://dx.doi.org/10.2147/CEG.S32368 Received: 29 March 2012 Accepted: 17 May 2012 Published: 05 July 2012 Rejane Mattar, Daniel Ferraz de Campos Mazo, Flair Jos¨¦ Carrilho Department of Gastroenterology, University of S o Paulo School of Medicine, S o Paulo, Brazil Abstract: Most people are born with the ability to digest lactose, the major carbohydrate in milk and the main source of nutrition until weaning. Approximately 75% of the world's population loses this ability at some point, while others can digest lactose into adulthood. This review discusses the lactase-persistence alleles that have arisen in different populations around the world, diagnosis of lactose intolerance, and its symptomatology and management. %K hypolactasia %K lactase persistence %K lactase non-persistence %K lactose %K LCT gene %K MCM6 gene %U https://www.dovepress.com/lactose-intolerance-diagnosis-genetic-and-clinical-factors-peer-reviewed-article-CEG