%0 Journal Article
%T Adiposity factors are not related to the presence of colorectal adenomas
%A Chronis A
%A Thomopoulos K
%A Sapountzis A
%A Triantos C
%A Kalafateli M
%A Kalofonos HP
%A Nikolopoulou V
%J Clinical and Experimental Gastroenterology
%D 2011
%I Dove Medical Press
%R http://dx.doi.org/10.2147/CEG.S25594
%X diposity factors are not related to the presence of colorectal adenomas Original Research (1924) Total Article Views Authors: Chronis A, Thomopoulos K, Sapountzis A, Triantos C, Kalafateli M, Kalofonos HP, Nikolopoulou V Published Date November 2011 Volume 2011:4 Pages 257 - 261 DOI: http://dx.doi.org/10.2147/CEG.S25594 Aris Chronis, Konstantinos Thomopoulos, Apostolos Sapountzis, Christos Triantos, Maria Kalafateli, Charalampos Kalofonos, Vassiliki Nikolopoulou Department of Internal Medicine, Division of Gastroenterology, University Hospital, Patras, Greece Purpose: Adiposity has been thought to be related to colorectal carcinogenesis. The aim of this study was to explore any association between obesity factors and the presence of colorectal adenoma, a potential precancerous lesion. Patients and methods: Two hundred and six consecutive patients undergoing colonoscopy without colorectal cancer were enrolled in the study. Anthropometric measures and other adiposity-related laboratory variables including insulin resistance and serum adiponectin levels were recorded and correlated with the presence of adenoma. Results: Colorectal adenoma was detected in 68/206 patients (33%), tubular adenoma(s) in 38 patients, and tubulovillous or villous in 30 patients. Twenty-one patients (10.2%) had at least one proximal polyp. The size of the largest adenoma was ¡Ü10 mm in 40 patients and >10 mm in 28 patients. No statistically significant difference was observed in body mass index, waist circumference, fasting plasma glucose concentration, insulin, homeostatic metabolic assessment, cholesterol, low-density lipoproteins, high-density lipoprotein, or triglycerides between patients with and without adenoma. In addition, there was no difference in plasma adiponectin between patients with adenoma (11.1 ¡À 6 ¦Ìg/mL) and controls (10.2 ¡À 7.8 ¦Ìg/mL). Furthermore, no significant difference in any parameter was found between patients with advanced adenoma and no advanced adenoma, nor between patients with proximal or distal tumors. Conclusion: This study found that the presence of colorectal adenoma is not correlated with any adiposity factor. Moreover, obesity does not appear to be associated with the site or the presence of more advanced lesions.
%K adiposity
%K colorectal adenoma
%K polyp
%K adiponectin
%U https://www.dovepress.com/adiposity-factors-are-not-related-to-the-presence-of-colorectal-adenom-peer-reviewed-article-CEG