%0 Journal Article
%T Memantine: Reality and Potentiality
%A Rita Moretti
%A Paola Torre
%A Cristina Vilotti
%A Davide Manganaro
%A Luca Zanet and Rodolfo M. Antonello
%J Drug Target Insights
%D 2012
%I 
%X Memantine protects cultured neurons from excitotoxin-induced cell-death; it attenuated loss of cholinergic neurons in the CNS induced by injection of NMDA into the basal forebrain of rats. It has been shown that memantine induced production of brain-derived neurotrophic factor (BDNF), a substance shown to promote survival and differentiation of CNS neuron. Due to the preclinical effects of memantine owing to its anti-ischemic and anti-excitotoxic properties, recent clinical ef cacy has been demonstrated in patients with advanced dementia of vascular origins. Therefore, it has been employed in different trials, in vascular dementia, showing a potential bene t and no unbearable side effects. Different studies under- line the possible role of memantine in Parkinson Disease.
%U http://www.la-press.com/memantine-reality-and-potentiality-article-a771