%0 Journal Article
%T GRIM-19: A Double-edged Sword that Regulates Anti-Tumor and Innate Immune Responses
%A Shreeram C. Nallar
%A Sudhakar Kalakonda
%A Peng Sun and Dhan V. Kalvakolanu
%J Translational Oncogenomics
%D 2012
%I 
%X Gene associated with retinoid-interferon-¦Â-induced mortality (GRIM)¡ª19, was originally identifi ed as a critical regulatory protein necessary for Interferon-¦Â-Retinoic acid-induced cell death. Overexpression of GRIM-19 activates cell death and its suppression or inactivation promotes cell growth. GRIM-19 targets multiple proteins/pathways for exerting growth control and cell death. However, GRIM-19 is also required for normal cellular processes. In addition, viruses ¡®hijack¡¯ GRIM-19 for their survival. Intracellular bacterial infections and bacterial products have been reported to induce the expression of GRIM-19. In this review, we will discuss the current status of GRIM-19 in growth control and innate immune response.
%U http://www.la-press.com/grim-19-a-double-edged-sword-that-regulates-anti-tumor-and-innate-immu-article-a613