%0 Journal Article
%T Dupuytren's Contracture in Alabama HFE Hemochromatosis Probands
%A James C. Barton
%A and J. Clayborn Barton
%J Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders
%D 2012
%I 
%R 10.4137/CMAMD.S9935
%X Background: Dupuytren's contracture (DC) and HFE hemochromatosis occur in some of the same at-risk populations and present with similar comorbid conditions. Methods: We estimated DC prevalence in two cohorts of white Alabama hemochromatosis probands (294 C282Y homozygotes, 67 C282Y/H63D compound heterozygotes) in a retrospective study. We performed logistic regressions on DC using the following independent variables: age, body mass index, heavy ethanol consumption, serum ferritin, elevated serum AST/ALT, non-alcoholic fatty liver disease, viral hepatitis, cirrhosis, and diabetes. Results: One man and two women with C282Y homozygosity had DC (prevalence 1.02%; 95% CI 0.35%-2.96%). A man with C282Y/H63D had DC (prevalence 1.49%; 95% CI 0.26%-7.98%). DC occurred as an autosomal dominant trait in his kinship. In regression analyses, no single variable predicted DC. We observed no new DC cases after the diagnosis of hemochromatosis (mean follow-up 12.9 ¡À 7.5 years (1 SD), and 9.0 ¡À 5.1 years, respectively). Conclusions: Our prevalence estimates of DC in white Alabama hemochromatosis probands are similar to those found in the white US population cohorts. DC risk was unrelated to the variables we studied.
%U http://www.la-press.com/dupuytrens-contracture-in-alabama-hfe-hemochromatosis-probands-article-a3312