%0 Journal Article
%T Aberrant overexpression of vascular endothelial growth factor in pancreatic ductal adenocarcinoma is associated with aggressive clinical behavior
%A Naomi Y Jiang
%A Bruce A Woda
%A Liping Zhang
%A et al
%J Pathology and Laboratory Medicine International
%D 2010
%I Dove Medical Press
%R http://dx.doi.org/10.2147/PLMI.S10619
%X berrant overexpression of vascular endothelial growth factor in pancreatic ductal adenocarcinoma is associated with aggressive clinical behavior Original Research (3089) Total Article Views Authors: Naomi Y Jiang, Bruce A Woda, Liping Zhang, et al Published Date July 2010 Volume 2010:2 Pages 85 - 90 DOI: http://dx.doi.org/10.2147/PLMI.S10619 Naomi Y Jiang1, Bruce A Woda2, Liping Zhang2, Suyang Hao2, Karen A Dresser2, Di Lu2 1Massachusetts Institute of Technology, Worcester, MA, USA; 2Department of Pathology, University of Massachusetts Medical Center, Worcester, MA, USA Abstract: Pancreatic adenocarcinoma is a leading cause of cancer-related deaths in the United States. In this study, we studied vascular endothelial growth factor (VEGF) expression in -pancreatic adenocarcinoma by immunohistochemical staining. Clinical follow-up and survival data were analyzed. We determined that VEGF was aberrantly overexpressed in a subset of primary pancreatic adenocarcinoma. Statistically, VEGF overexpression was associated with higher stage, higher grade, and lymph node metastasis (P < 0.001, P = 0.012, and P < 0.005, respectively). Additionally, patients of this subset had a much shorter overall survival than patients without VEGF overexpression, as evidenced by Kaplan¨CMeier plots and the log-rank test (P = 0.001). The 5-year overall survival rate was 17% in patients with VEGF overexpression compared to 52% in patients without VEGF overexpression. The median survival was only 13 months for patients with VEGF overexpression compared to 65 months for patients without. In conclusion, VEGF is a biomarker that identifies a subset of pancreatic ductal adenocarcinoma with aggressive clinical behavior.
%K pancreatic adenocarcinoma
%K VEGF
%K cancer
%U https://www.dovepress.com/aberrant-overexpression-of-vascular-endothelial-growth-factor-in-pancr-peer-reviewed-article-PLMI