%0 Journal Article
%T Impact of Overweight and Obesity on Left Ventricular Diastolic Function and Value of Tissue Doppler Echocardiography
%A Antoine Kossaify and Nayla Nicolas
%J Clinical Medicine Insights: Cardiology
%D 2012
%I 
%R 10.4137/CMC.S11156
%X Background: Diastolic dysfunction is a common cause of heart failure with preserved systolic function in obese patients. Objective: To assess diastolic function in a series of overweight and obese patients using conventional and tissue Doppler echocardiography. Setting and method: University hospital; left ventricular diastolic function was evaluated in 99 patients (mean age 61.59 ¡À 13.9 years); body mass index and waist circumference were assessed, and patients were subdivided into three groups according to their body mass index (kg/m2): [normal, (18.5¨C24.9); overweight, (25¨C29.9); obese, (>29.9)]. Peak early (E) and late (A) transmitral flow and peak early (E ) diastolic mitral annulus velocities were measured. Results: Diastolic dysfunction was significantly higher in the overweight/obese groups compared to the normal body mass index group. The analysis was made with regard to waist circumference and other clinical characteristics, and multivariate regression analysis showed a direct and independent effect of body mass index on diastolic function [OR: 2.75; CI: 1.34¨C5.67; P = 0.006]. Discussion was made in view of the latest clinical data. Also, an insight into normal weight obesity is presented and discussed. Conclusion: Overweight and obesity are found to have an independent negative impact on diastolic function as assessed by tissue Doppler imaging.
%U http://www.la-press.com/impact-of-overweight-and-obesity-on-left-ventricular-diastolic-functio-article-a3555