%0 Journal Article %T Protein Multifunctionality: Principles and Mechanisms %A Joseph Z. Zaretsky and Daniel H. Wreschner %J Translational Oncogenomics %D 2012 %I %X In the review, the nature of protein multifunctionality is analyzed. In the first part of the review the principles of structural/functional organization of protein are discussed. In the second part, the main mechanisms involved in development of multiple functions on a single gene product(s) are analyzed. The last part represents a number of examples showing that multifunctionality is a basic feature of biologically active proteins. %U http://www.la-press.com/protein-multifunctionality-principles-and-mechanisms-article-a785