%0 Journal Article
%T QTc Interval and QT Dispersion in Patients with Thalassemia Major: Electrocardiographic (EKG) and Echocardiographic Evaluation
%A Taysir S. Garadah
%A Salah Kassab
%A Najat Mahdi
%A Ahmed Abu-Taleb and Anwer Jamsheer
%J Clinical Medicine Insights: Cardiology
%D 2012
%I 
%R 10.4137/CMC.S4472
%X Background: Doppler echocardiographic studies in patients with ¦Â-Thalassemia Major (¦Â-TM) had shown different patterns of left ventricle (LV) systolic and diastolic dysfunctions. Aim: This cross-sectional study was designed to study the LV systolic and diastolic function in patients with ¦Â-TM using Pulsed Doppler (PD) Echocardiogram and assess the QTc interval and QT dispersion (QTd) on 12 leads ECG. Method: All patients were evaluated clinically as well as by echocardiography and 12 leads ECG. The study included patients with ¦Â-TM (n = 38, age 15.7 ¡À 8.9 years), compared with an age-matched healthy control group (n = 38, age 15.9 ¡À 8.9 years). Results: In 38 patients with ¦Â-TM Compared with healthy control group, The QTc interval and the QTd dispersion on ECG were increased with no significant difference mode echo showed that ¦Â-TM patients have thicker LV septal wall index (0.659 ¡À 0.23 vs. 0.446 ¡À 0.219 cm/M2, P < 0.001), posterior wall index (0.659 ¡À 0.235 vs. 0.437 ¡À 0.214 cm/M2, P < 0.01), and larger LVEDD index is (3.99 ¡À 0.48 vs. 2.170 ¡À 0.57 cm/M2. P < 0.05). Pulsed Doppler showed high LV trans-mitral E wave velocity index (70.818 ¡À 10.139 vs. 57.532 ¡À 10.139, P < 0.05) and E/A ratio (1.54 vs.1.23, P < 0.01). The duration of deceleration time index (DT) and isovolumic relaxation time index (IVRT) were significantly shorter in patients with ¦Â-TM (150.234 ¡À 20.0.23 vs. 167.123 ¡À 167.123 ¡À 19.143 msec/ M2, P < 0.01) and (60.647 ¡À 6.77 vs. 75.474 ¡À 5.83 msec/M2, P < 0.001), respectively. The tricuspid valve velocity in patients with ¦Â-TM was significantly higher than controls (2.993 ¡À 0.569 vs. 1.93 ¡À 0.471 m/sec, respectively, P < 0.01), with calculated pulmonary artery pressure of 2.4 times the control (36.0 vs. 14.8 mmHg). However, the LVEF% or fractional shortening were not significantly different. Conclusion: In this study, ¦Â-thalassemia major patients compared with controls have differences of QT dispersion and corrected QT interval that is of no statistical significance. A significantly thicker LV wall and LV diastolic filling indices are suggestive of restrictive diastolic pattern. These data indicate that LV diastolic abnormalities compromised initially in patients with ¦Â-thalassemia major.
%U http://www.la-press.com/qtc-interval-and-qt-dispersion-in-patients-with-thalassemia-major-elec-article-a1934