%0 Journal Article
%T N -Alkylation of 4-Trichloromethylpyrimidinones: Synthesis of Some New and Interesting Modified Nucleoside Analogues
%A Nilo Zanatta
%A Patr¨ªcia B. Brondani
%A Simone S. Amaral
%A Taritza D. Oliveira
%A Helio G. Bonacorso and Marcos A.P. Martins
%J Organic Chemistry Insights
%D 2012
%I 
%X The N1-alkylation of 4-(trichloromethyl)pyrimidin-2(1H)-one, 4-methoxy-4-(trichloromethyl)-3,4-dihydropyrimidin- 2(1H)-one, and 5-bromo-4-methoxy-4-(trichloromethyl)-3,4-dihydropyrimidin-2(1H)-one with selected alkylating agents such as 2-chloroacetamide, diethyl 2-bromomalonate, and 5-bromo-1,1,1-trichloro-4-methoxypent-3-en-2-one, is presented. Further reactions of 1-[5,5,5-trichloro-2-methoxy-4-oxo-penten-2-yl]4-trichloromethyl-pyrimidin-2(1H)-one with primary amines and aminoalcohols furnished a series of unexpected new acyclic nucleoside analogues.
%U http://www.la-press.com/n--alkylation-of-4-trichloromethylpyrimidinones-synthesis-of-some-new--article-a1768