%0 Journal Article
%T Parathyroid Hormone¡¯s Acute Effect on Vasodilatory Function
%A P. Farahnak
%A L. Lind
%A K. Mattala and I-L. Nilsson
%J Clinical Medicine Insights: Endocrinology and Diabetes
%D 2012
%I 
%R 10.4137/CMED.S4650
%X Parathyroid hormone (PTH) seems to affect the risk of cardiovascular disease. The aim of the present study was to investigate PTH¡¯s acute effect on endothelial vasodilatory function in forearm resistance vessels. Ten healthy subjects underwent forearm venous occlusion plethysmography. We measured forearm blood flow at baseline and at a stable, locally increased PTH level after intra-arterial infusion of metacholine and nitroprusside. The contralateral arm served as a control. Ionized calcium (Ca++) and PTH values were normal in all subjects at baseline (1.26 ¡À 0.02 mM/L, 3.6 ¡À 1.2 pM/L). After 30 minutes of PTH infusion, the PTH level increased in the active arm (13.8 ¡À 4.0 pM/L P , 0.01), while the Ca++ level was unchanged (1.25 ¡À 0.04; mM/L). Both the PTH and the Ca++ level in the contralateral arm remained unchanged, which indicates no systemic influence. The endothelial-dependent vasodilation was inversely correlated to the Ca++ level at baseline (r =  0.75, P , 0.05) and after PTH infusion (r =  0.68, P , 0.05). The vasodilatory function was not affected during PTH-infusion.
%U http://www.la-press.com/parathyroid-hormonersquos-acute-effect-on-vasodilatory-function-article-a2013