%0 Journal Article
%T Letter to the Editor: Does Dicer Expression Affect shRNA Processing?
%A Neil Senzer
%A Donald Rao and John Nemunaitis
%J Gene Regulation and Systems Biology
%D 2012
%I 
%X Elevated Dicer and Drosha mRNA levels have been documented across a range of tumor types (including ovarian carcinoma) by a number of investigators without any demonstrable correlation with patient survival nor evidence of interference with shRNA processing. A recent publication by Merritt et al. (NEJM 359(25):2641-50, 2008) reporting their findings in patients with ovarian carcinoma reach opposite conclusions. Further study will be needed to resolve this issue.
%U http://www.la-press.com/letter-to-the-editor-does-dicer-expression-affect-shrna-processing-article-a1507