%0 Journal Article
%T Longitudinal Brain Size Measurements in APP/PS1 Transgenic Mice
%A Trevor J. Vincent
%A Jonathan D. Thiessen
%A Laryssa M. Kurjewicz
%A Shelley L. Germscheid
%A Allan J. Turner
%A Peter Zhilkin
%A Murray E. Alexander and Melanie Martin
%J Magnetic Resonance Insights
%D 2012
%I 
%R 10.4137/MRI.S5885
%X There appear to be species differences among the effects of gene mutations related to familial Alzheimer¡¯s disease on the brain during aging. To gain a better understanding of the effects of the Swedish mutation of amyloid precursor protein and the mutant form of human presenilin 1 on mice, commercially available mice from Jackson Laboratory were studied. Three dimensional T2*-weighted imaging was used to monitor the size of brains of APP/PS1 mice monthly, from 6 to 13 months of age. No significant difference was measured in the size of the medial-lateral width, dorsal-ventral height, rostral-caudal length or the volume of the APPSwe/ PS1 mouse brain. Faster and higher-resolution imaging methods are needed to accurately determine if small volume or shape changes occur in mouse brains with age or gene mutations.
%U http://www.la-press.com/longitudinal-brain-size-measurements-in-appps1-transgenic-mice-article-a2286