%0 Journal Article %T Chemo-Enzymatic Synthesis of Ester-Linked 2-Phenylindole-3-Carboxaldehyde-Monosaccharide Conjugate as Potential Prodrug %A Kei Shimoda %A Manabu Hamada %A Hiroshi Yokoi and Hiroki Hamada %J Biochemistry Insights %D 2012 %I %R 10.4137/BCI.S9961 %X Chemo-enzymatic synthesis of ester-linked 2-phenylindole-3-carboxaldehyde-glucose conjugate (2-phenylindole-3-carboxyl-10 -O-¦Â-D-glucosyl ester) was achieved by using plant cell cultures as biocatalysts. The anticancer agent, 2-phenylindole-3-carboxaldehyde, induced apoptosis in cells, whereas 2-phenylindole-3-carboxyl-10 -O-¦Â-D-glucosyl ester showed no cytotoxicity and induced no apoptosis. %U http://www.la-press.com/chemo-enzymatic-synthesis-of-ester-linked-2-phenylindole-3-carboxaldeh-article-a3317