%0 Journal Article
%T Chemo-Enzymatic Synthesis of Ester-Linked 2-Phenylindole-3-Carboxaldehyde-Monosaccharide Conjugate as Potential Prodrug
%A Kei Shimoda
%A Manabu Hamada
%A Hiroshi Yokoi and Hiroki Hamada
%J Biochemistry Insights
%D 2012
%I 
%R 10.4137/BCI.S9961
%X Chemo-enzymatic synthesis of ester-linked 2-phenylindole-3-carboxaldehyde-glucose conjugate (2-phenylindole-3-carboxyl-10 -O-¦Â-D-glucosyl ester) was achieved by using plant cell cultures as biocatalysts. The anticancer agent, 2-phenylindole-3-carboxaldehyde, induced apoptosis in cells, whereas 2-phenylindole-3-carboxyl-10 -O-¦Â-D-glucosyl ester showed no cytotoxicity and induced no apoptosis.
%U http://www.la-press.com/chemo-enzymatic-synthesis-of-ester-linked-2-phenylindole-3-carboxaldeh-article-a3317