%0 Journal Article
%T In Vitro and In Vivo Phagocytic Ability of Mouse B-1 Cells
%A RR Novaes e Brito
%A BA Cortez
%A GM Machado-Santelli
%A P Xander
%A BH De Lorenzo
%A HC Oliveira
%A FG Thies
%A ES Kioshima
%A JT Maricato
%A JD Lopes and M Mariano
%J Immunology and Immunogenetics Insights
%D 2012
%I 
%R 10.4137/III.S6156
%X B-1 cells are a peculiar subpopulation of B cells found in the peritoneal and pleural cavities in mice. These cells are typically IgM+ and CD11b+. B-1 cells are able to migrate from the peritoneal cavity to non-specific inflammatory sites in mice. In addition, they can differentiate into mononuclear phagocyte-like cells in vitro; however, it is still unknown whether B-1 cells are capable of performing phagocytosis in vivo. Here we further characterized B-1 cells as phagocytes in vitro, and we investigated their ability to phagocytose apoptotic cells and bacteria in vivo. Our results demonstrate that B-1 phagocytes are able to uptake apoptotic thymocytes and Escherichia coli bacteria, both in vitro and in vivo. These findings indicate that along with macrophages, B-1 phagocytic cells might play a role in fundamental processes such as tissue remodeling, resolution of inflammation and pathogen clearance.
%U http://www.la-press.com/in-vitro-and-in-vivo-phagocytic-ability-of-mouse-b-1-cells-article-a2374