%0 Journal Article
%T Serum Hepatitis C virus and hepatitis B surface antigenaemia in Nigerian patients with acute Icteric hepatitis
%A SO Ola
%A JA Otegbayo
%A GN Odaibo
%A OD Olaleye
%A OI Olubuyide
%J West African Journal of Medicine
%D 2002
%I 
%X Acute hepatitis is common in Nigeria and hepatitis B virus (HBV) infection has been a major aetiological factor. However, the role of Hepatitis C virus (HCV) infection is yet undetermined. Forty-five consecutive Nigerian patients with acute Icteric hepatitis (AIH) attending the Medical Clinic of the University College Hospital, Ibadan, Nigeria and 45 healthy adult Nigerians (controls) were studied for evidence of infection with both viruses. Questionnaire on risk procedures, which predispose to acquisition of both HBV and HCV infections were administered to the patients. Blood samples were collected from all the subjects and tested for antibody to HCV (anti-HCV) and Hepatitis B surface Antigen (HbsAg) using the second generation enzyme Linked Immunoassay (Monolisa -R, Sansofi, Pasteur; France). Anti-HCV was detected in 21(47%) and 17(38%) of the patients and controls respectively. The corresponding prevalence of HbsAg were 38(84%) and 11(24%), p<0.001. Hepatitis b virus infection was found to occur more than HCV infection in the patients with AIH but similar among the controls. Combined HBV and HCV infection occurred more frequently among the patients (42.1%) than in the control (11%); (<0.001). Although there was no significant difference in the HCV infection between the two groups, isolated HCV infection is commoner in the control than in the patients with AIH, (p<0.001). Similarly, single HCV infection is commoner than lone HBV infection among the control, p<0.05. In summary, this study shows that while both HBV and HCV infections are common in Nigeria, AIH may be more associated with HBV than HCV in the country. R¨¦sum¨¦ La fr¨¦quence de l'h¨¦patite aigue est not¨¦e au Nig¨¦ria, et l'infection du virus H¨¦patite B(VBH) reste toujours menacant comme la trait ¨¦tiologique principal. Cependant, on n'arrive pas ¨¤ delimiter le role que joue l'infection du virus H¨¦patite C(VCH). Quarante cinq maladies consecutives Nig¨¦rians avec leteric H¨¦patite aigue (AIH) se sont pr¨¦sent¨¦s ¨¤ la Clinique M¨¦dicale de Coll¨¦ge Hospitali¨¦r Universitaire d'Ibadan au Nig¨¦ria, d'autre part, on avait ¨¦tudi¨¦ 45 adultes Nig¨¦rians bien portant, (comme cas de t¨¦moins) comme signe de l'infection des deux virus. Questionnaire sur les dispositions des risques qui precedes l'attaque d'infections des deux VBH et VCH ¨¦tait donn¨¦ aux maladies. On avait passer par la prise de sang de tous les maladies et examine afin de signaler les anticorps par rapport au VCH (Anti-VCH) et le H¨¦patite B surface Antigen (Hbs Ag) avec la m¨¦thode de la deuxi¨¨me generation. On avait pu d¨¦pister la enzyme li¨¦. Immunoassay (monolisa ¨C R sansofi, Pasteur, France). Anti-VCH dans 21 soit 47% et 17 soit 38% chez les maladies et les cas de t¨¦moins respectivement. Les frequencies correspondents de Hbs Ag ¨¦taient 38, soit 84% et 11 soit 24%, P<0,001. On avait remarqu¨¦ la fr¨¦quence de l'infection de Virus B H¨¦patite ¨¦tait plus ¨¦lev¨¦e que l'nfection VCH chez des maladies avec AIH mais similair chez les cas de t¨¦moins. La
%U http://www.ajol.info/index.php/wajm/article/view/28033