%0 Journal Article
%T Simultaneous Quantification of Paracetamol and Meloxicam in Tablets by High Performance Liquid Chromatography
%A M Induri
%A BR Mantripragada
%A RP Yejella
%A PR Kunda
%A M Arugula
%A R Boddu
%J Tropical Journal of Pharmaceutical Research
%D 2011
%I University of Benin
%X Purpose: To develop and validate a simple, rapid and inexpensive RP-HPLC method for the simultaneous estimation of paracetamol and meloxicam in tablets. Methods: For the analysis of the drugs, chromatographic analysis was performed on XTerra symmetry C18 column (100 ¡Á 4.6 mm, 5 ¦Ì particle size) with mobile phase consisting of methanol and phosphate buffer (pH 9.2) in the ratio of 50:50 v/v, at a flow rate of 0.8 mL/min and eluents monitored at 244 nm. The method was validated for linearity, accuracy, precision, robustness and application for assay as per International Conference on Harmonization (ICH) guidelines. Results: The retention times of paracetamol and meloxicam were 2.467 and 4.971 min, respectively. The calibration curves of peak area versus concentration, which was linear from 5 - 60 ¦Ìg/mL for paracetamol and 1 - 12 ¦Ìg/mL for meloxicam, had regression coefficient (r2) greater than 0.999. The method had the requisite accuracy, precision, and robustness for simultaneous determination of paracetamol and meloxicam in tablets. Conclusion: The proposed method is simple, low-cost, accurate, precise and can be successfully employed in routine quality control for the simultaneous analysis of paracetamol and meloxicam in tablets.
%U http://www.ajol.info/index.php/tjpr/article/view/69563