%0 Journal Article
%T Activation of NF-¨º B signalling pathway by inflammatory regulators and associated drug discovering
%A S Xu
%A X Li
%A X Shen
%A X Guo
%A Y Peng
%A Y Liu
%A Q Zhao
%A S Feng
%A F Wang
%J Internet Journal of Medical Update - EJOURNAL
%D 2011
%I Dr. Arun Kumar Agnihotri
%X Intracellular signalling transduction plays a pivotal role in cell activation, and the regulation of gene transcription needs the involvement of series of nuclear factors. Nuclear transcription factor- kappa B, one of the key factors in mediating gene expression, takes an essential part in a body of physiological and pathological processes. Endotoxin lipopolysaccharides, proinflammatory cytokine tumor necrosis factor-alpha, liganddependent immunocellular B cell receptor and inflammation-associated bradykinin are four typical NF-¨ºB activation pathways. Activating or inhibitory drugs focused on NF-¨ºB may be strongly related with the therapy of associated diseases, and the exploration of effective and economical drugs concentrated on NF-¨ºB is crucial.
%U http://www.ajol.info/index.php/ijmu/article/view/68193