%0 Journal Article
%T Molecular Characterization of Acquired Tolerance of Tumor Cells to Picropodophyllin (PPP)
%A Jamileh Hashemi
%A Claire Worrall
%A Daiana Vasilcanu
%A M£¿rten Frykn£¿s
%A Luqman Sulaiman
%A Mohsen Karimi
%A Wen-Hui Weng
%A Weng-Onn Lui
%A Christina Rudduck
%A Magnus Axelson
%A Helena Jernberg-Wiklund
%A Leonard Girnita
%A Olle Larsson
%A Catharina Larsson
%J PLOS ONE
%D 2012
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0014757
%X Picropodophyllin (PPP) is a promising novel anti-neoplastic agent that efficiently kills tumor cells in vitro and causes tumor regression and increased survival in vivo. We have previously reported that PPP treatment induced moderate tolerance in two out of 10 cell lines only, and here report the acquired genomic and expression alterations associated with PPP selection over 1.5 years of treatment.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0014757