%0 Journal Article %T Reduction of Cross-Reactive Carbohydrate Determinants in Plant Foodstuff: Elucidation of Clinical Relevance and Implications for Allergy Diagnosis %A Heidi Kaulf¨¹rst-Soboll %A Melanie Mertens %A Randolf Brehler %A Antje von Schaewen %J PLOS ONE %D 2012 %I Public Library of Science (PLoS) %R 10.1371/journal.pone.0017800 %X A longstanding debate in allergy is whether or not specific immunoglobulin-E antibodies (sIgE), recognizing cross-reactive carbohydrate determinants (CCD), are able to elicit clinical symptoms. In pollen and food allergy, ¡Ý20% of patients display in-vitro CCD reactivity based on presence of ¦Á1,3-fucose and/or ¦Â1,2-xylose residues on N-glycans of plant (xylose/fucose) and insect (fucose) glycoproteins. Because the allergenicity of tomato glycoallergen Lyc e 2 was ascribed to N-glycan chains alone, this study aimed at evaluating clinical relevance of CCD-reduced foodstuff in patients with carbohydrate-specific IgE (CCD-sIgE). %U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0017800