%0 Journal Article
%T In vitro inhibition of camel hepatic glutathione transferases by selected organic azides
%A MAA Sarhan
%J Egyptian Journal of Biology
%D 2010
%I Egyptian British Biological Society
%X Glutathione S-transferases (GST) are a group of multifunctional enzymes, widely distributed in both animal and plant kingdom. The present study was carried out to investigate the inhibitory potential of three structurally related organic azides (n-propyl azide, n-butyl azide, and heptyl azide) on camel hepatic GST activity in vitro. The mean inhibition constants (Ki) were estimated to be 0.419 ¡À 0.068, 0.501 ¡À 0.068, and 0.563 ¡À 0.036 mM for n-propyl azide, n-butyl azide, and heptyl azide respectively, using Lineweaver-Burk plots. These results indicated that hepatic GST was sensitive to the organic azides used.
%U http://www.ajol.info/index.php/ejb/article/view/56590