%0 Journal Article
%T Conversion of Vernonia galamensis oil to pyridinyl-vernolamides and their antimicrobial activities
%A M.N. Mbugua
%A A.O. Yusuf
%A P.M. Gitu
%A B.M. Bhatt
%J Bulletin of the Chemical Society of Ethiopia
%D 2007
%I Chemical Society of Ethiopia
%X Vernonia oil obtained by Soxhlet extraction from the seeds of Vernonia galamensis ssp. nairobensis was reacted with 2-aminopyridine, 2-(aminomethyl)pyridine and 2-(aminoethyl)pyridine using a 1:3 mole ratio of vernonia oil to amine at varied temperatures to give the corresponding vernolamides. The expected vernolamide from the reaction of 2-aminopyridine and the oil was not formed. N-(2-pyridinylmethyl)vernolamide and N-(2-pyridinylethyl)vernolamide exhibited antibacterial activity that was shown to be higher against gram-positive (Bacillus subtilis) than gram-negative (Escherichia coli) bacteria. The vernolamides did not show any antifungal activity.   KEY WORDS: Vernonia galamensis, 2-Aminopyridine, N-(2-pyridinylmethyl)vernolamide,     N-(2-pyridinylethyl)vernolamide, Antimicrobial activity     Bull. Chem. Soc. Ethiop. 2007, 21(1), 103-110.
%U http://www.ajol.info/index.php/bcse/article/view/61384