%0 Journal Article
%T Multiple Cancer/Testis Antigens Are Preferentially Expressed in Hormone-Receptor Negative and High-Grade Breast Cancers
%A Yao-Tseng Chen
%A Dara S. Ross
%A Rita Chiu
%A Xi K. Zhou
%A Yunn-Yi Chen
%A Peishan Lee
%A Syed A. Hoda
%A Andrew J. Simpson
%A Lloyd J. Old
%A Otavia Caballero
%A A. Munro Neville
%J PLOS ONE
%D 2012
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0017876
%X Cancer/testis (CT) antigens are protein antigens normally expressed only in germ cells of testis, and yet are expressed in a proportion of a wide variety of human cancers. CT antigens can elicit spontaneous immune responses in cancer patients with CT-positive cancers, and CT antigen-based therapeutic cancer vaccine trials are ongoing for ˇ°CT-richˇ± tumors. Although some previous studies found breast cancer to be ˇ°CT-poorˇ±, our recent analysis identified increased CT mRNA transcripts in the ER-negative subset of breast cancer.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0017876