%0 Journal Article %T R-¨CLipoic acid and acetyl-L-carnitine optimal combinations in MPP+- induced cellular model of Parkinson¡¯s disease %A AA Akindahunsi %J Biokemistri %D 2009 %I Nigerian Society for Experimental Biology %X Mitochondrial insufficiency and oxidative damage contribute to the etiopathology of Parkinson¡¯s disease (PD). However, there is a dearth of information on the protective activities against PD of mitochondrial nutrients, safe for coenzyme Q10. In the present study, the PD protective effects of two mitochondrial nutrients, R-¨Clipoic acid (LA) and acetyl-Lcarnitine (ALC), as well as their combinations using 1-methyl-4-phenylpyridinium ion (MPP+)-treated SKN-MC human neuroblastoma cells as a model of PD was examined. Pretreatment of cells with LA (1-100 ¨¬M), ALC (1-100 ¨¬M) or LA-ALC (1:10; 10:100; 100:100 ¨¬M) combinations showed protective effects against MPP+-induced toxicity of cells. The best concentrations were LA-ALC (1:10 ¨¬M) combination, LA (10 ¨¬M) and ALC (100 ¨¬M) in that order, thus indicating a synergy by the mitochondrial nutrients. This could be a promising strategy in combating PD and other neurodegenerative disorders. %U http://www.ajol.info/index.php/biokem/article/view/56460