%0 Journal Article
%T Syntheses and spectral studies of novel ciprofloxacin derivatives
%A Pradeep Yadav
%A Y.C. Joshi
%J Bulletin of the Chemical Society of Ethiopia
%D 2008
%I Chemical Society of Ethiopia
%X Reaction of 1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (ciprofloxacin) with thiazole/benzothiazole diazonium chloride afforded piperazine substituted ciprofloxacin derivative. The acid part of these derivatives was further condensed with various ¦Â-diketones to get 1-cyclopropyl-6-fluoro-4-oxo-7-(4-(thiazol-2-yldiazenyl)piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid derivatives (5a-e) and 7-(4-(benzo[d]thiazol-2-yldiazenyl)piperazin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid derivatives (5f-j). Structures of these compounds were established on the basis of spectral studies.   KEY WORDS: Ciprofloxacin, Thiazole, Benzothiazole, ¦Â-Diketone     Bull. Chem. Soc. Ethiop. 2008, 22(3), 459-464.
%U http://www.ajol.info/index.php/bcse/article/view/61246