%0 Journal Article
%T Contractile effect of PGF2¦Á and PGE2 on isolated branches of uterine and ovarian artery in different days of estrous cycle and early pregnancy in pigs
%A J. Skipor
%A M. Pikuli¨½ska
%A S. Stefa¨½czyk-Krzymowska
%J Polish Journal of Veterinary Sciences
%D 2010
%I 
%R 10.2478/v10181-010-0009-0
%X The contractile effects of PGF2¦Á (3 ¡Á 10-6 to 10-4 M) and PGE2 (10-7 to 10-5 M) were examined on isolated branches of ovarian artery (OA) and extramyometrial branches of uterine artery (UA) collected from pigs in the luteal (day 10-12) and follicular phase (day 17-20) of the estrous cycle, and during early pregnancy (day 10-12). Strong contraction was demonstrated in both arteries during all investigated periods in response to PGF2¦Á, which was significantly higher (P <0.01) than to PGE2, being negligible in the follicular phase. In UA, the effective dose of PGF2¦Á (ED50) amounted 7.9 ¡Á 10-6 M and 6.3 ¡Á 10-6 M in the luteal and follicular phase, and 5.0 ¡Á 10-6 M in early pregnancy. ED50 for PGE2 reached 5.0 ¡Á 10-7 M in the luteal phase, and 4.1 ¡Á 10-7 M in early pregnancy. For both prostaglandins, the contraction was much stronger (P <0.01) in OA than in UA branches. In OA, the ED50 for PGF2¦Á was 1.2 ¡Á 10-5 M in the luteal phase and was significantly higher (P <0.05) than in the follicular phase (3.1 ¡Á 10-6 M) and early pregnancy (2.7 ¡Á 10-6 M). ED50 for PGE2 amounted 7.3 ¡Á 10-7 M in the luteal phase and 1.7 ¡Á 10-7 M in early pregnancy. Studies showed the influence of the estrous cycle and early pregnancy on OA branches sensitivity to the contractile effect of PGF2¦Á and the lack of this effect on UA branches, and the influence of the estrous cycle on UA and OA branch contraction in response to PGE2.
%K uterine artery
%K ovarian artery
%K PGF 2¦Á
%K PGE 2
%K pregnancy
%K pigs
%U http://versita.metapress.com/content/77u8933450742803/?p=88b9e8e23eef43c8a41d44799928e68e&pi=3