%0 Journal Article
%T Synthesis and pharmacological evaluation of 3-cyclohexyl-2-substituted hydrazino-3H-quinazolin-4-ones as analgesic and anti-inflammatory agents
%A Veerachamy Alagarsamy
%A Durairaj Shankar
%A Viswas Raja Solomon
%A Rajendra Vasant Sheorey
%A Periyasamy Parthiban
%J Acta Pharmaceutica
%@ 1846-9558
%D 2009
%I 
%R 10.2478/v10007-009-0004-0
%X A series of novel 3-cyclohexyl-2-substituted hydrazino-quinazolin-4(3H)-ones were synthesized by reacting the amino group of 3-cyclohexyl-2-hydrazino quinazolin-4(3H)-one with a variety of aldehydes and ketones. The starting material, 3-cyclohexyl-2-hydrazino quinazolin-4(3H)-one, was synthesized from cyclohexyl amine. Title compounds were investigated for analgesic, anti-inflammatory and ulcerogenic behavior. The compound 3-cyclohexyl-2-(1-methylbutylidene-hydrazino)-3H-quinazolin-4-one (4c) emerged as the most active compound of the series and is moderately more potent in its analgesic and anti-inflammatory activities compared to the reference standard diclofenac sodium. Interestingly, test compounds showed only mild ulcerogenic potential when compared to acetylsalicylic acid.
%K quinazolin-4(3H)-one
%K analgesic activity
%K anti-inflammatory activity
%K ulcerogenicity
%U http://versita.metapress.com/content/7u7724h966581428/?p=e23b13a363df4ecabe5fbbbf469787e5&pi=5